استعرض مصدر Dementia, Thyroid Function and Serum Level of S100B


Dementia, Thyroid Function and Serum Level of S100B
Samia A. Abdul-Rahman, Egypt
SA Abdul-Rahman1
, SS Al saied1,WW Aly1
, SA Bastawy2
1
Geriatrics and Gerontology Department, Ain Shams University, Cairo, Egypt,
2
Ain Shams University Hospitals, Cardiothoracic surgical center labs,
Abbassea square, Cairo, Egypt.
Background: Dementia is a syndrome of acquired intellectual deficit resulting
in significant impairment of social and/or occupational functions. This syndrome
has shared clinical outcome that derives from multiple etiologies. Alzheimer’s
disease is the most common dementia in the elderly. The potential of
peripheral biochemical markers as complementary tools in the
neuropsychiatric evaluation of these patients has claimed further attention.
Clinical hypo- and hyperthyroidism are recognized causes of reversible dementia
but prior studies relating thyroid stimulating hormone (TSH) levels to cognitive
performance in clinically euthyroid persons have yielded inconsistent results.

Methods: We evaluated serum levels of S100B and thyroid functions in 58
dementia patients (28 AD patients, 10 vascular, 16 mixed dementia and 4 other
degenerative dementias) and in 56 community-dwelling elderly. All
participants were subjected to comprehensive geriatric assessment, and
dementia stage and subtype were verified using assessment tools. S100B and
TSH levels were measured in serum.

Results: Patients with dementia were significantly older than controls. They
also had significantly lower levels of S100B than controls (24.59±8.282 vs.
30.07±9.26 pg/ml) (P =0.001). Yet, the difference between S100B levels among
dementia subtypes was insignificant. Among dementia subtypes;
thyroid status was normal in all dementia subtypes except for AD. Patients with
AD had significantly high prevalence of thyroid disorders (12/28). No significant
correlation was found between S100B and thyroid status of the cases.

Conclusion: S100B levels are significantly lower among patients with dementia
but cannot be used for differentiation between dementia subtypes. Thyroid
disorders- both hypothyroid and hyperthyroid- are common among patients with
AD and should be routinely screened.


http://www.alz.co.uk/sites/default/files/dubai2013/adi-dubai-2013-abstracts.pdf

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