استعرض مصدر Safety profile of proton pump inhibitors according to the spontaneous reports of suspected adverse reactions

تعليق: تقرير من مرصد أسبانيا للأدوية. ومشاكل الإبصار كانت من المشاكل المشهورة وليس النادرة كما يظن البعض. Of the organ and system groups more commonly affected, diarrhea, myalgia, abnormal vision and hepatitis were selected for further analysis. وتعليق على موضوع الأنواع Nearly 8 times more reports for omeprazole compared to other drugs were found but a similar difference was observed in their consumption. وتعليق على شفاء مشاكل الإبصار بشكل عام The four adverse reactions analyzed were mainly reversible.. وتعليق على علاقة العمر بالأعراض تحدث عن الشباب فهل ضعف الإبصار موجود بكثرة في المسنين؟ Myalgia appears more often in younger patients than diarrhea, abnormal vision or hepatitis and shows longer periods of latency and recovery. وعن علاقة الإستهلاك بتقارير الأعراض الجانبية وهو تأكيد لنظريتنا :A direct relationship was found between consumption and the number of reports. Some organ and system groups were affected by more than one PPI and this showed a specific pattern of group toxicity to these pharmacological agents. 

Safety profile of proton pump inhibitors according to the spontaneous reports of suspected adverse reactions

Article in International journal of clinical pharmacology and therapeutics 44(11):548-56 · December 2006

DOI: 10.5414/CPP44548 · Source: PubMed

1st María Esther Salgueiro

2nd T Rubio

3rd A Hidalgo

4th Gloria Manso

Abstract

[corrected] To evaluate similarities and differences in safety among proton pump inhibitors (PPIs) under the usual conditions of prescription.

A search of spontaneous reports on adverse reactions associated with these drugs and registered between January 1, 2004 and December 31, 2004 was undertaken in the Spanish Pharmacovigilance System Database. We compared the frequency of reports with the consumption of PPIs, and analyzed the organ and system distribution for each PPI. Of the organ and system groups more commonly affected, diarrhea, myalgia, abnormal vision and hepatitis were selected for further analysis.

Nearly 8 times more reports for omeprazole compared to other drugs were found but a similar difference was observed in their consumption. Skin and appendage disorders were more frequently reported for omeprazole and rabeprazole, the urinary, female reproductive and endocrine systems for lansoprazole, musculoskeletal for omeprazole and esomeprazole, vision for pantoprazole, rabeprazole and esomeprazole, gastrointestinal tract for omeprazole and lansoprazole and liver and biliary systems for omeprazole, lansoprazole and pantoprazole. Myalgia appears more often in younger patients than diarrhea, abnormal vision or hepatitis and shows longer periods of latency and recovery. The four adverse reactions analyzed were mainly reversible.

A direct relationship was found between consumption and the number of reports. Some organ and system groups were affected by more than one PPI and this showed a specific pattern of group toxicity to these pharmacological agents. Some reports involved only lansoprazole and these require further analysis.

https://www.researchgate.net/publication/6622814_Safety_profile_of_proton_pump_inhibitors_according_to_the_spontaneous_reports_of_suspected_adverse_reactions

[[تصنيف:Proton pump inhibitors and vision]]