استعرض مصدر A systematic review of the economic evaluations of the different proton pump inhibitors (PPIs) marketed in Spain

==Conclusions==
• Omeprazole is the PPI with the best pharmacoeconomic profile and should be
used as the first choice.

• No arguments were found, from the perspective of the cost-effectiveness
analysis, for the use of a PPI other than omeprazole. In most of the indications,
this conclusion is due to the fact that there is no evidence to suggest that the
more expensive PPIs are more effective.

• The only case that may lead to certain doubts is the treatment of severe GERD
with esomeprazole which, when used in standard doses, showed this PPI to be
slightly superior to the rest, including omeprazole. This conclusion is
preliminary and needs to be confirmed through empirical studies. Likewise,
analyses of subgroups need to be carried out according to the severity of the
GERD.