استعرض مصدر Current Standings of the Proton Pump Inhibitor and Clopidogrel Co-Therapy: Review on an Evolving Field with the Eyes of the Gastroenterologist



 Digestion 2010;81:10–15  DOI: 10.1159/000243717
 Current Standings of the Proton Pump Inhibitor and Clopidogrel Co-Therapy: Review on an Evolving Field with '''the Eyes of the Gastroenterologist'''

ربما تكون مقالتنا مشاكل الأوميبراز بعين طبيب مسنين.


Márk Juhász László Herszényi Zsolt Tulassay
 2nd Department of Medicine, Semmelweis University, Budapest , Hungary


==Key Words==
Proton pump inhibitors  Clopidogrel  Myocardial infarction  Gastroprotection

==Abstract==
The negative effect of proton pump inhibitors (PPI) on
the antiplatelet function of clopidogrel has only recently
emerged on the horizon of cardiological interest. To date,
one can only find 10 peer-reviewed papers on PubMed on
this issue, although the increasing activity is unquestionable.
Besides publications, conference reports and official
web sites are therefore important sources of information. In
this field, the first step was made by an experimental study
proving the adverse effect of omeprazole on clopidogrel
function. Consequently, retrospective studies reported a
significant increase of major adverse cardiovascular events
among patients taking the combination of omeprazole and
clopidogrel. Based on the paucity of quality data and limitations
of studies conducted on this interaction, some are still
reluctant to confirm the pathogenic role of PPI and clopidogrel
interaction in the development of reinfarctions. One
step further ahead, admitting the risks related to the combination
of these two drugs, the next question to be decided
is whether we face a class effect, or thanks to the different metabolic pathways there are indeed relevant differences
among PPIs. There is a lot at stake, since the volume of patients
taking the dual aspirin-clopidogrel antiplatelet therapy
and thereby needing gastroprotection is immense, rendering
a huge responsibility to the societies and committees
who are making proposals on the selection of appropriate
PPIs.

http://www.karger.com/Article/PDF/243717

[[تصنيف:Proton pump inhibitors and vision]]