استعرض مصدر Selection of Proton Pump Inhibitors (PPIs) for Formulary Inclusion Using an Objective Scoring System in Malaysia



Journal of Applied Pharmaceutical Science 02 (03); 2012: 17-24

ISSN: 2231-3354

H/P: 012-5899 180

Selection of Proton Pump Inhibitors (PPIs) for Formulary Inclusion Using an Objective Scoring System in Malaysia

Lynette Lim and Mohamed Izham M.I

ABSTRACT

The main aim of this study was to develop an objective Drug Evaluation Scoring
System (DESS) by determining criteria for differentiation among 5 PPI drugs available in the
market i.e. esomeprazole, lansoprazole, omeprazole, pantoprazole and rabeprazole. Secondly,
was to assign weightage according to its importance of the criteria. Thirdly, was to determine the
scores and rank the PPI drugs. In developing DESS, 200 points was assigned for the clinical
documentation criterion, 300 points for the clinical efficacy criterion, 200 points for the safety
criterion and 300 points for the cost criterion. The higher the assigned score, the higher
importance the criterion is. The criteria were designed in the format of questionnaire to enable
participants to allocate scores according to their perception on the importance of the criteria.
Self-administered questionnaires were distributed to 165 specialists and medical officers. Study
findings from the scoring system found that all PPI drugs have very negligible difference in
clinical efficacy and clinical safety. Omeprazole was found to be the most cost economical PPI
in the government hospitals. The DESS was able to compare and rank PPI drugs based on the
scoring system and also assist in the selection of PPI drugs into the drug formulary.

Keywords: ‘Drug evaluation’, ‘Drug formulary, ‘Formulary management’, ‘Drug selection’,
‘Scoring tool’

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[[تصنيف:Proton pump inhibitors and vision]]