استعرض مصدر Survival and Prognostic Factors for Hepatocellular Carcinoma: an Egyptian Multidisciplinary Clinic Experience


Abstract

Background: Hepatocellular carcinoma (HCC) is a dismal tumor with a high incidence, prevalence and poor
prognosis and survival. Management of HCC necessitates multidisciplinary clinics due to the wide heterogeneity
in its presentation, different therapeutic options, variable biologic behavior and background presence of chronic
liver disease. We studied the different prognostic factors that affected survival of our patients to improve future
HCC management and patient survival. Materials and Methods: This study is performed in a specialized
multidisciplinary clinic for HCC in Kasr El Eini Hospital, Cairo University, Egypt. We retrospectively analyzed
the different patient and tumor characteristics and the primary mode of management applied to our patients.
Further analysis was performed using univariate and multivariate statistics. Results: During the period February
2009 till February 2013, 290 HCC patients presented to our multidisciplinary clinic. They were predominantly
males and the mean age was 56.5±7.7years. All cases developed HCC on top of cirrhosis that was mainly due
to HCV (71%). Most of our patients were Child-Pugh A (50%) or B (36.9%) and commonly presented with
small single lesions. Transarterial chemoembolization was the most common line of treatment used (32.4%).
The overall survival was 79.9% at 6 months, 54.5% at 1 year and 22.4% at 2 years. Serum bilirubin, site of the
tumor and type of treatment were the significant independent prognostic factors for survival. Conclusions: Our
main prognostic variables are the bilirubin level, the bilobar hepatic affection and the application of specific
treatment (either curative or palliative). Multidisciplinary clinics enhance better HCC management.

Keywords: Hepatocellular carcinoma - multidisciplinary - prognosis - survival

http://apocpcontrol.org/paper_file/issue_abs/Volume15_No9/3915-3920%202.3%20Ashraf%20Omar%20Abdelaziz.pdf

[[تصنيف:رعاية تلطيفية في مصر]]