«Martindale: The Complete Drug Reference Omeprazole»: الفرق بين المراجعتين

من ويكيتعمر
اذهب إلى: تصفح، ابحث
(أنشأ الصفحة ب'تعليق: مرجع محترم مثل مارتندل يعتبر الأوميبراز تأثيره على البصر نادر وهذا ربما يحتاج لمراجعة...')
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مراجعة 19:16، 21 أكتوبر 2016

تعليق: مرجع محترم مثل مارتندل يعتبر الأوميبراز تأثيره على البصر نادر وهذا ربما يحتاج لمراجعة. وأيضاً الإسهال يحدث بكثرة في المسنين وأيضاً عيوب دراسات الأعراض الجانبية يذكرها مارتندل ولهذا تقارير الحالات قد تقدم قيمة مضافة لدراسات الأعراض الجانبية. --احمد شوقي محمدين 19:16، 21 أكتوبر 2016 (ت ع م)


Adverse Effects (Latest modification: 12-Oct-2009)

Proton pump inhibitors are generally well tolerated, and adverse effects are relatively infrequent. The adverse effects reported most often with omeprazole and other proton pump inhibitors have been headache, diarrhoea, and skin rashes; they have sometimes been severe enough to require stopping treatment. Other effects include pruritus, dizziness, fatigue, constipation, nausea and vomiting, flatulence, abdominal pain, arthralgia and myalgia, urticaria, and dry mouth. Isolated cases of photosensitivity, bullous eruption, erythema multiforme, Stevens-Johnson syndrome, and toxic epidermal necrolysis have occurred. Hypersensitivity reactions, including fever, bronchospasm, angioedema, and anaphylaxis have been reported. Effects on the CNS include occasional insomnia, somnolence, and vertigo; reversible confusional states, agitation, depression, and hallucinations have occurred in severely ill patients. Raised liver enzymes, and isolated cases of hepatitis, jaundice, hepatic failure, and hepatic encephalopathy, have been reported. Other adverse effects reported rarely include paraesthesia, blurred vision, alopecia, stomatitis, increased sweating, taste disturbances, peripheral oedema, malaise, hyponatraemia, blood disorders (including agranulocytosis, leucopenia, and thrombocytopenia), gynaecomastia, impotence, and interstitial nephritis.

Proton pump inhibitors may increase the risk of gastrointestinal infections because of their acid suppressive effects. Early toxicological studies identified carcinoid-like tumours of the gastric mucosa in rats given very high doses of omeprazole over long periods (see under Gastrointestinal Tumours, ).

Incidence of adverse effects

Prescription-event monitoring for 16 205 patients prescribed omeprazole, 17 329 prescribed lansoprazole, and 11 541 prescribed pantoprazole indicated that adverse events were reported infrequently, with the most common being gastrointestinal disturbances and headache. The incidences of diarrhoea, the most commonly reported event, per 1000 days of exposure, were 0.18 for omeprazole, 0.39 for lansoprazole, and 0.23 for pantoprazole. Despite the inherent biases of such a cohort study, there did seem to be some evidence that lansoprazole might be associated with a somewhat greater risk of diarrhoea, particularly in the elderly.1


http://www.valeant.com.mx/cif/repositorio/archivos/detalles/20121113_100426_115_4.pdf