A cohort study of the ocular safety of anti-ulcer drugs

تعليق: الإستخدام بالوريد. وربما أدوية علاج القرحة الأخرى. يؤثر على الإبصار--احمد شوقي محمدين 21:18، 15 أكتوبر 2016 (ت ع م)

Br J Clin Pharmacol. 1996 Aug;42(2):213-6.

A cohort study of the ocular safety of anti-ulcer drugs.

García Rodríguez LA1, Mannino S, Wallander MA, Lindblom B.

Abstract

1. Recently, some cases have been reported where intravenous use of omeprazole was followed by loss of vision. We followed up a cohort of close to 140,000 persons during periods of treatment and non-treatment with five anti-ulcer drugs. 2. The relative risk of vascular disorders of the eye during use of omeprazole compared with non-use was 1.8 (95% CI 0.5-6.0). Use of other anti-ulcer drugs was associated with a similar risk of vascular disorders. The relative risk associated with current use of any anti-ulcer drug was 1.9 (95% CI 1.1-3.4). We did not find a single case of optic inflammatory disorder during treatment with any of the five anti-ulcer drugs. 3. These results do not suggest a major increased risk for vascular or inflammatory disorders of the eye associated with use of omeprazole or other anti-ulcer drugs. Comment in

Ocular safety of anti-ulcer drugs. [Br J Clin Pharmacol. 1997]

PMID: 8864320 PMCID: PMC2042664

http://onlinelibrary.wiley.com/doi/10.1046/j.1365-2125.1996.40211.x/abstract