Fundus autofluorescence patterns and optical coherence tomography in geographic atrophy secondary to AMD

Lipofuscin derives mainly from phagocytosed photoreceptor outer segments and accumulates in RPE lysosomes, where one of its many compounds, A2E (N-retinylidene-N-retinylethanol-amine), increases the pH by inhibition of ATPase proton pump function, difficulting its phagocitation and inducing cellular apoptosis(6,7).