Potential Uses of Intravenous Proton Pump Inhibitors to Control Gastric Acid Secretion
Potential Uses of Intravenous Proton Pump Inhibitors to Control Gastric Acid Secretion
Digestion 2000;62:73–81
Safety of IV PPIs
The safety of oral PPIs is well established; the most common adverse events associated with these agents are diarrhea, nausea, skin disorders and headache [36]. Based on the data from studies with IV omeprazole and pantoprazole, it appears that IV PPIs are also well tolerated [47, 77]. Reports from Germany of impaired vision and blindness associated with IV administration of omeprazole were originally of some concern [78]. However, a review of clinical trial data and epidemiologic studies with oral omeprazole did not confirm this association; it was likely a result of confounding coincident conditions [79]. Studies in the United States of IV pantoprazole demonstrated no ophthalmic effects.
