Safety Review of Proton Pump Inhibitors and Possible Increased Risk of Fracture of the Hip, Wrist, and Spine

تعليق: الإستخدام أكثر من سنة. مشكلة طبعا في المسنين--احمد شوقي محمدين 20:12، 20 أكتوبر 2016 (ت ع م)

Safety Review of Proton Pump Inhibitors and Possible Increased Risk of Fracture of the Hip, Wrist, and Spine 6/28/2010

The Saudi Food and Drug Authority (SFDA) has revised the labels for a class of drugs known as proton pump inhibitors (PPIs) to include new safety information about a possible increased risk of fractures of the hip, wrist, and spine with the use of these medications at higher doses or long duration (more than one year).

The new safety information is based on several epidemiological studies that reported an increased risk of fractures of hip, wrist, and spine with PPIs use. Some studies found that those at greatest risk for these fractures are usually receiving high doses of PPIs or used them for one year or more .The majority of the studies evaluated individuals 50 years of age or older and the increased risk of fractures primarily was observed in this age group.

https://www.sfda.gov.sa/en/drug/news/Pages/768-ar-28+-+6.aspx